Endocrine Abstracts

Introduction: In addition to its well known effects on calcium homeostasis and bone metabolism, growing evidences shows that vitamin D plays an important role in regulation of cancer angiogenesis, cell apoptosis, differentiation, and proliferation. Vitamin D acts through vitamin D receptor (VDR), an intracellular nuclear receptor. It was found an association between different cancer histotypes and single nucleotide polymorphisms (SNPs) of VDR. Despite the close relationship be...

Introduction: Acne is a common skin disease that occasionally can be influenced by endocrine abnormalities. In females, a clear relationship has been highlight between acne onset and peripheral insulin resistance and hyperinsulinemia, whereas few data are available in male. The aim of this study was to investigate the relationship between acne and insulin resistance as well as other metabolic impairment in male subjects with acne.Methods/design: Twenty-t...

GH replacement is widely used in adults with hypopituitarism, but its effect on tumor occurrence and pituitary tumor recurrence is unknown. Furthermore, in literature there are scant with short follow-up time. The available data do not seem to suggest that rhGH replacement increased the incidence of regrowth of pituitary tumor and of cancer in adults with GHD, provided that IGF1 concentrations remain within the normal range for age.The aim of our study w...

Objective: To evaluate Vitamin D levels and bone metabolism in adult patients with cystic fibrosis (CF).Patients and methods: One hundred patients with CF (53 F, 47 M; age 29±8 years). and 100 healthy controls were enrolled. Patients were assessed through clinical, and laboratory investigations. Evaluation of serum 25 hydroxy vitamin D (25OHD), vertebral fractures (quantitative morphometric analysis) and bone mineral density (BMD) at lumbar spine an...

Introduction: Several cross-sectional studies evidence the association between hypovitaminosis D, obesity, insulin resistance (IR), and polycystic ovary syndrome (PCOS) cohorts, although the role of obesity per se is still debatable. Increased leptin-to-adiponectin ratio (L/A) and low-grade chronic inflammation markers, both due to accumulation of dysfunctional adipocytes, have been recently reported in PCOS. Aim of our study was to investigate the relative roles of obe...

Background: Craniopharyngiomas are benign tumors of the parasellar and sellar region. Patients with craniopharyngioma, treated with surgery, have comorbidities such as obesity and multiple pituitary deficiencies.Aim: To evaluate the metabolic parameters of patients with craniopharyngioma treated with surgery.Methods: We recruited 20 patients with craniopharyngioma (M=11, 46.6±12.6) and 20 patients (M=10, 53.5&#17...

To evaluate vitamin D levels in relapsing remitting (RR) and secondary progressive (SP) courses of multiple sclerosis (MS) and to evaluate correlations between vitamin D and clinical features of disease progression, in a southern Italy population. 63 (41 RR and 22 SP) ‘naive’ MS patients (47 females, 16 males aged 37.7±5.7 years) and 63 healthy controls were enrolled. Patients were assessed through clinical, magnetic resonance imaging (MRI) and laboratory invest...

Introduction: Italy is considered a country with high prevalence of 25 OH vitamin D deficiency. Changes in vitamin D serum levels were linked with the onset and progression of several diseases, including osteoporosis and cardiovascular diseases. The hypopituitary patients show several comorbidities like cardiovascular diseases and osteoporosis.Purpose: To evaluate the prevalence of vitamin D deficiency in hypopituitary patients.Pat...

Aggressive pituitary tumors are classically defined as pituitary tumors with large size, rapid growth and massive invasion of surrounding anatomical structures. This is a group of pituitary tumors with biological behavior between pituitary adenomas and carcinomas and includes a new group of pituitary tumor, defined atypical adenoma, characterized by the presence of invasive growth and combination of increased mitotic activity and a Ki-67 labeling index >3%. The aim of this...

Patients with hyperprolactinemia have impaired bone metabolism and bone mineral density (BMD) partially represents bone’s health.To evaluate vitamin D levels, PTH, Ca and P, BMD and bone morphometry in patients with prolactin-secreting pituitary adenomas.Forty-four patients (30 W, 40±11 years, BMI 27.6±5 kg/m2) underwent to lumbar and femoral DEXA, to vertebral morphometry by X-ray and was calculated the S...